SMAD4_HUMAN.H11DI.0.A motif - HOmo sapiens COmprehensive MOdel COllection

Transcription factor

SMAD4
(GeneCards)

Model

SMAD4_HUMAN.H11DI.0.A

Model type

Dinucleotide PWM

LOGO

LOGO (reverse complement)

Data source

ChIP-Seq

Model release

HOCOMOCOv10

Model length

Quality

Motif rank

Consensus

nnbWGKCTvdCWSYYnnnnnn

Best auROC (human)

0.882

Best auROC (mouse)

0.926

Peak sets in benchmark (human)

Peak sets in benchmark (mouse)

Aligned words

500

TF family

SMAD factors {7.1.1}

TF subfamily

Co-activating Smads (Co-Smad) {7.1.1.2}

HGNC

HGNC:6770

EntrezGene

GeneID:4089
(SSTAR profile)

UniProt ID

SMAD4_HUMAN

UniProt AC

Q13485
(TFClass)

Comment

Downloads

pcm
pwm
alignment
threshold to P-value grid

Standard thresholds

P-value	Threshold
0.001	8.83656
0.0005	10.74381
0.0001	14.712860000000001

GTEx tissue expression atlas

SMAD4 expression

ReMap ChIP-seq dataset list

SMAD4 datasets

Motifs in JASPAR

MA0513.1 (SMAD2::SMAD3::SMAD4; Homo sapiens)

MA1153.1 (Smad4; Mus musculus)

PCM

	AA	AC	AG	AT	CA	CC	CG	CT	GA	GC	GG	GT	TA	TC	TG	TT
01	23.446	22.009	30.427	26.517	39.376	65.675	9.032	64.517	18.436	30.07	24.048	18.369	8.754	31.459	48.936	38.929
02	14.483	28.187	35.26	12.081	31.954	66.535	22.353	28.371	13.513	47.011	38.883	13.036	14.131	58.009	43.752	32.441
03	25.506	6.1	7.123	35.352	60.885	13.551	2.373	122.933	28.173	29.578	13.328	69.169	17.057	3.284	7.508	58.081
04	0.0	0.857	129.097	1.667	0.868	2.792	44.142	4.711	0.0	2.101	27.14	1.09	3.973	7.551	271.339	2.671
05	0.0	0.0	0.0	4.841	0.0	2.012	1.038	10.251	8.429	20.788	79.513	362.987	0.0	3.703	1.955	4.482
06	0.868	7.561	0.0	0.0	0.899	23.682	0.0	1.923	0.966	76.855	0.846	3.839	0.917	378.009	0.0	3.635
07	0.0	0.0	0.0	3.651	2.978	2.141	0.0	480.988	0.0	0.0	0.0	0.846	0.0	0.0	0.0	9.396
08	1.736	0.0	1.242	0.0	0.0	1.081	0.0	1.06	0.0	0.0	0.0	0.0	106.431	112.363	254.297	21.79
09	7.564	4.021	48.917	47.665	57.739	11.072	3.799	40.834	52.15	39.485	102.072	61.832	3.61	0.0	7.902	11.339
10	1.086	104.667	8.827	6.484	3.097	48.493	0.0	2.989	1.642	154.439	4.665	1.943	2.047	148.048	5.472	6.102
11	0.0	1.933	4.175	1.764	343.516	29.811	28.868	53.451	7.695	3.112	0.951	7.206	2.653	2.217	6.443	6.205
12	21.895	266.678	46.987	18.303	1.834	32.559	0.0	2.68	3.063	29.447	5.488	2.439	0.0	57.633	6.369	4.625
13	0.908	16.307	7.595	1.983	52.3	237.49	1.214	95.313	3.822	36.464	7.671	10.886	5.516	12.442	6.322	3.767
14	11.268	9.327	16.346	25.606	29.825	45.476	6.196	221.205	2.704	3.953	6.831	9.313	10.197	27.23	20.409	54.113
15	6.046	17.554	22.984	7.411	29.399	16.717	4.084	35.786	10.073	11.515	16.003	12.191	44.336	57.351	105.681	102.868
16	19.091	21.538	26.701	22.525	23.679	32.163	0.908	46.388	31.315	48.868	26.13	42.439	13.609	43.457	52.498	48.693
17	19.811	19.822	22.102	25.958	24.486	40.24	1.944	79.355	26.755	18.179	19.589	41.713	42.554	23.75	41.958	51.783
18	64.462	15.197	22.572	11.376	37.94	28.006	3.313	32.731	28.488	27.413	18.056	11.636	55.135	28.097	62.591	52.986
19	64.527	22.156	37.042	62.3	29.331	16.102	2.879	50.4	20.238	18.171	31.639	36.483	22.093	30.274	27.275	29.089
20	28.471	12.749	44.707	50.261	27.804	30.75	0.0	28.15	11.115	26.824	35.214	25.682	17.912	65.513	55.301	39.546

PWM

	AA	AC	AG	AT	CA	CC	CG	CT	GA	GC	GG	GT	TA	TC	TG	TT
01	-0.283	-0.345	-0.026	-0.162	0.229	0.736	-1.212	0.719	-0.519	-0.038	-0.258	-0.523	-1.241	0.007	0.444	0.217
02	-0.755	-0.102	0.119	-0.931	0.022	0.749	-0.33	-0.095	-0.822	0.404	0.216	-0.857	-0.779	0.613	0.333	0.037
03	-0.2	-1.584	-1.438	0.122	0.661	-0.82	-2.439	1.36	-0.102	-0.054	-0.836	0.788	-0.595	-2.154	-1.388	0.614
04	-4.4	-3.235	1.409	-2.734	-3.226	-2.297	0.342	-1.825	-4.4	-2.542	-0.139	-3.063	-1.982	-1.383	2.15	-2.336
05	-4.4	-4.4	-4.4	-1.8	-4.4	-2.579	-3.099	-1.09	-1.278	-0.401	0.926	2.441	-4.4	-2.045	-2.603	-1.871
06	-3.226	-1.381	-4.4	-4.4	-3.202	-0.273	-4.4	-2.617	-3.151	0.893	-3.244	-2.013	-3.188	2.482	-4.4	-2.062
07	-4.4	-4.4	-4.4	-2.058	-2.241	-2.526	-4.4	2.722	-4.4	-4.4	-4.4	-3.244	-4.4	-4.4	-4.4	-1.174
08	-2.701	-4.4	-2.966	-4.4	-4.4	-3.07	-4.4	-3.084	-4.4	-4.4	-4.4	-4.4	1.217	1.271	2.086	-0.355
09	-1.381	-1.971	0.444	0.418	0.608	-1.015	-2.022	0.265	0.507	0.231	1.175	0.676	-2.069	-4.4	-1.339	-0.992
10	-3.066	1.2	-1.234	-1.527	-2.206	0.435	-4.4	-2.237	-2.746	1.588	-1.834	-2.608	-2.564	1.546	-1.686	-1.584
11	-4.4	-2.612	-1.936	-2.688	2.386	-0.047	-0.078	0.532	-1.365	-2.201	-3.162	-1.427	-2.342	-2.497	-1.533	-1.568
12	-0.351	2.133	0.404	-0.526	-2.656	0.041	-4.4	-2.333	-2.215	-0.059	-1.683	-2.415	-4.4	0.606	-1.544	-1.842
13	-3.195	-0.639	-1.377	-2.591	0.51	2.017	-2.983	1.107	-2.017	0.153	-1.368	-1.032	-1.679	-0.903	-1.551	-2.03
14	-0.999	-1.181	-0.637	-0.197	-0.046	0.371	-1.57	1.946	-2.325	-1.986	-1.478	-1.182	-1.095	-0.136	-0.42	0.544
15	-1.593	-0.567	-0.303	-1.4	-0.06	-0.615	-1.956	0.134	-1.107	-0.978	-0.658	-0.922	0.346	0.602	1.21	1.183
16	-0.485	-0.367	-0.155	-0.323	-0.274	0.028	-3.195	0.391	0.002	0.443	-0.177	0.303	-0.816	0.326	0.514	0.439
17	-0.449	-0.448	-0.341	-0.183	-0.241	0.25	-2.607	0.924	-0.153	-0.533	-0.46	0.286	0.305	-0.271	0.292	0.5
18	0.718	-0.708	-0.321	-0.989	0.192	-0.108	-2.146	0.046	-0.091	-0.129	-0.54	-0.967	0.562	-0.105	0.688	0.523
19	0.719	-0.339	0.168	0.684	-0.063	-0.652	-2.27	0.473	-0.428	-0.533	0.012	0.153	-0.342	-0.031	-0.134	-0.071
20	-0.092	-0.879	0.354	0.471	-0.115	-0.016	-4.4	-0.103	-1.012	-0.151	0.118	-0.194	-0.547	0.734	0.565	0.233