SOX2_HUMAN.H11MO.0.A motif - HOmo sapiens COmprehensive MOdel COllection

We, Russian scientists of the autosome team, are depressed by the dire events caused by Russian military actions in Ukraine.
We express our condolences to all affected people and sincerely hope for a prompt transition to peace.

Model info

Transcription factor

SOX2
(GeneCards)

Model

SOX2_HUMAN.H11MO.0.A

Model type

Mononucleotide PWM

LOGO

LOGO (reverse complement)

Data source

ChIP-Seq

Model release

HOCOMOCOv11

Model length

13

Quality

A

Motif rank

0

Consensus

bbYCTTTGTbhbb

Best auROC (human)

0.944

Best auROC (mouse)

0.922

Peak sets in benchmark (human)

67

Peak sets in benchmark (mouse)

109

Aligned words

500

TF family

SOX-related factors {4.1.1}

TF subfamily

Group B {4.1.1.2}

HGNC

EntrezGene

GeneID:6657
(SSTAR profile)

UniProt ID

UniProt AC

P48431
(TFClass)

Comment

Downloads

pcm
pwm
alignment
threshold to P-value grid

Standard thresholds

P-value	Threshold
0.001	5.81351
0.0005	6.702415
0.0001	8.36516

GTEx tissue expression atlas

SOX2 expression

ReMap ChIP-seq dataset list

Motifs in JASPAR

MA0142.1 (Pou5f1::Sox2; Mus musculus)

MA0143.1 (Sox2; Mus musculus)

MA0143.2 (Sox2; Mus musculus)

MA0143.3 (Sox2; Mus musculus)

PCM

	A	C	G	T
01	52.0	114.0	123.0	211.0
02	18.0	176.0	131.0	175.0
03	5.0	321.0	40.0	134.0
04	8.0	364.0	5.0	123.0
05	146.0	5.0	0.0	349.0
06	0.0	1.0	1.0	498.0
07	0.0	0.0	0.0	500.0
08	8.0	78.0	404.0	10.0
09	31.0	9.0	0.0	460.0
10	23.0	127.0	104.0	246.0
11	53.0	206.0	38.0	203.0
12	51.0	156.0	68.0	225.0
13	38.0	198.0	129.0	135.0

PWM

	A	C	G	T
01	-0.86	-0.091	-0.016	0.519
02	-1.868	0.339	0.046	0.333
03	-2.961	0.936	-1.114	0.069
04	-2.584	1.061	-2.961	-0.016
05	0.154	-2.961	-4.4	1.019
06	-4.4	-3.903	-3.903	1.373
07	-4.4	-4.4	-4.4	1.377
08	-2.584	-0.464	1.165	-2.394
09	-1.358	-2.484	-4.4	1.294
10	-1.64	0.016	-0.181	0.671
11	-0.841	0.495	-1.163	0.48
12	-0.879	0.219	-0.599	0.582
13	-1.163	0.455	0.031	0.076